Mapping drug-induced changes in cerebral R(2)* by Multiple Gradient Recalled Echo functional MRI

被引：41

作者：

Chen, Q ^{[1
]}

Andersen, AH ^{[1
]}

Zhang, Z ^{[1
]}

Ovadia, A ^{[1
]}

Gash, DM ^{[1
]}

Avison, MJ ^{[1
]}

机构：

[1] UNIV KENTUCKY,SCH MED,MAGNET RESONANCE IMAGING & SPECT CTR,LEXINGTON,KY 40536

来源：

MAGNETIC RESONANCE IMAGING | 1996年 / 14卷 / 05期

关键词：

Basal ganglia; Parkinson's disease; levodopa; rhesus; dopamine; BOLD; brain mapping; MRI; striatum; HUMAN VISUAL-CORTEX; HUMAN BRAIN; BLOOD OXYGENATION; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; HEMIPARKINSONIAN MONKEYS; SENSORY STIMULATION; PHOTIC-STIMULATION; RHESUS-MONKEYS; SIGNAL CHANGES; ACTIVATION;

D O I：

10.1016/0730-725X(95)02100-8

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A Multiple Gradient Recalled Echo MRI sequence was used to map spatial and temporal changes in the rate of MR signal decay (R(2)(*)) in response to L-3,4-dihydroxyphenylalanine (levodopa) in the striatal dopaminergic system of a rhesus monkey unilaterally lesioned with 4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP). R(2)(*) decreased significantly in the right (dopamine depleted) putamen and caudate following levodopa. More focal areas of smaller R(2)(*) decline were also observed in these structures in the left hemisphere. The observed spatial and temporal patterns of R(2)(*) change support the view that the method is monitoring changes in neural activity.

引用

页码：469 / 476

页数：8

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