DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans - A review

被引：37

作者：

Geijtenbeek, TBH ^{[1
]}

van Vliet, SJ ^{[1
]}

van Duijnhoven, GCF ^{[1
]}

Figdor, CG ^{[1
]}

van Kooyk, Y ^{[1
]}

机构：

[1] Univ Nijmegen, Dept Tumor Immunol, Med Ctr St Radboud, NL-6525 EX Nijmegen, Netherlands

来源：

PLACENTA | 2001年 / 22卷

关键词：

D O I：

10.1053/plac.2001.0674

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dendritic cells (DC) capture micro-organisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present in antigenic form to resting T cells and thus initiate adaptive immune responses. Here we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC, but instead promotes efficient infection in trans of cells that express CD-C and chemokine receptors. The interaction of DC-SIGN with HIV gp120 may be an important target for therapeutic intervention and vaccine development. (C) 2001 IFPA and Harcourt Publishers Ltd.

引用

页码：S19 / S23

页数：5

共 31 条

[1] CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1 [J].

Alkhatib, G ;

Combadiere, C ;

Broder, CC ;

Feng, Y ;

Kennedy, PE ;

Murphy, PM ;

Berger, EA .

SCIENCE, 1996, 272 (5270) :1955-1958

[2] Th1-and Th2-type lymphokine-assisted induction and release of chemokine receptors from primary human trophoblast cells [J].

Athanassakis, I ;

Papadimitriou, L ;

Koumantakis, E ;

Vassiliadis, S .

HUMAN IMMUNOLOGY, 2000, 61 (07) :651-657

[3] ACUTELY INFECTED LANGERHANS CELLS ARE MORE EFFICIENT THAN T-CELLS IN DISSEMINATING HIV TYPE-1 TO ACTIVATED T-CELLS FOLLOWING A SHORT CELL-CELL CONTACT [J].

AYEHUNIE, S ;

GROVES, RW ;

BRUZZESE, AM ;

RUPRECHT, RM ;

KUPPER, TS ;

LANGHOFF, E .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1995, 11 (08) :877-884

[4] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[5]

BarrattBoyes SM, 1997, ADV EXP MED BIOL, V417, P71

[6] SUSCEPTIBILITY OF DENDRITIC CELLS TO HIV-1 INFECTION IN-VITRO [J].

CAMERON, PU ;

LOWE, MG ;

CROWE, SM ;

ODOHERTY, U ;

POPE, M ;

GEZELTER, S ;

STEINMAN, RM .

JOURNAL OF LEUKOCYTE BIOLOGY, 1994, 56 (03) :257-265

[7] INFECTION AND APOPTOTIC CELL-DEATH OF CD4+ T-CELLS DURING AN IMMUNE-RESPONSE TO HIV-1-PULSED DENDRITIC CELLS [J].

CAMERON, PU ;

POPE, M ;

GEZELTER, S ;

STEINMAN, RM .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1994, 10 (01) :61-71

[8]

CAMERON PU, 1992, CLIN EXP IMMUNOL, V88, P226, DOI 10.1111/j.1365-2249.1992.tb03066.x

[9] DENDRITIC CELLS EXPOSED TO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TRANSMIT A VIGOROUS CYTOPATHIC INFECTION TO CD4+ T-CELLS [J].

CAMERON, PU ;

FREUDENTHAL, PS ;

BARKER, JM ;

GEZELTER, S ;

INABA, K ;

STEINMAN, RM .

SCIENCE, 1992, 257 (5068) :383-386

[10] The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates [J].

Choe, H ;

Farzan, M ;

Sun, Y ;

Sullivan, N ;

Rollins, B ;

Ponath, PD ;

Wu, LJ ;

Mackay, CR ;

LaRosa, G ;

Newman, W ;

Gerard, N ;

Gerard, C ;

Sodroski, J .

CELL, 1996, 85 (07) :1135-1148

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