The Dysregulation of Cytokine Networks in Systemic Lupus Erythematosus

被引:99
作者
Apostolidis, Sokratis A. [1 ]
Lieberman, Linda A. [1 ]
Kis-Toth, Katalin [1 ]
Crispin, Jose C. [1 ]
Tsokos, George C. [1 ]
机构
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
PLASMACYTOID DENDRITIC CELLS; REGULATORY T-CELL; INDUCIBLE GENE-EXPRESSION; ALPHA PRODUCING CELLS; INTERFERON-ALPHA; I INTERFERON; IFN-ALPHA; IL-2; PRODUCTION; B-LYMPHOCYTES; LYMPH-NODES;
D O I
10.1089/jir.2011.0029
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Systemic lupus erythematosus (SLE) is an autoimmune disease associated with chronic immune activation and tissue damage. Organ damage in SLE results from the deposition of immune complexes and the infiltration of activated T cells into susceptible organs. Cytokines are intimately involved in every step of the SLE pathogenesis. Defective immune regulation and uncontrolled lymphocyte activation, as well as increased antigen presenting cell maturation are all influenced by cytokines. Moreover, expansion of local immune responses as well as tissue infiltration by pathogenic cells is instigated by cytokines. In this review, we describe the main cytokine abnormalities reported in SLE and discuss the mechanisms that drive their aberrant production as well as the pathogenic pathways that their presence promotes.
引用
收藏
页码:769 / 779
页数:11
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