Glial and neuronal control of brain blood flow

被引：1812

作者：

Attwell, David ^{[1
]}

Buchan, Alastair M. ^{[2
]}

Charpak, Serge ^{[3
]}

Lauritzen, Martin ^{[4
,5
]}

MacVicar, Brian A. ^{[6
,7
]}

Newman, Eric A. ^{[8
]}

机构：

[1] UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England

[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Med, Acute Stroke Programme, Oxford OX3 9DU, England

[3] Univ Paris 05, Lab Neurophysiol & New Microscopies, CNRS, INSERM,U603,UMR 8154, F-75006 Paris, France

[4] Univ Copenhagen, Inst Neurosci & Pharmacol, Dept Clin Neurophysiol, DK-2600 Glostrup, Denmark

[5] Glostrup Cty Hosp, DK-2600 Glostrup, Denmark

[6] Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada

[7] Univ British Columbia, Dept Psychiat, Vancouver, BC V6T 2B5, Canada

[8] Univ Minnesota, Dept Neurosci, Minneapolis, MN 55455 USA

来源：

NATURE | 2010年 / 468卷 / 7321期

基金：

英国医学研究理事会; 英国惠康基金; 加拿大健康研究院; 美国国家卫生研究院; 欧洲研究理事会;

关键词：

CORTICAL SPREADING DEPRESSION; ACTIVITY-DEPENDENT INCREASES; RAT CEREBELLAR CORTEX; TISSUE-PLASMINOGEN ACTIVATOR; EXCITATORY SYNAPTIC ACTIVITY; NITRIC-OXIDE; FUNCTIONAL HYPEREMIA; CEREBRAL-ISCHEMIA; OXYGEN-CONSUMPTION; CEREBROVASCULAR REACTIVITY;

D O I：

10.1038/nature09613

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.

引用

页码：232 / 243

页数：12

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