High yields of meta-substituted amination products in the SNAr substitution of benzenes

被引：27

作者：

Brown, GR ^{[1
]}

Foubister, AJ ^{[1
]}

Ratcliffe, PD ^{[1
]}

机构：

[1] Zeneca Pharmaceut, Cardiovasc Metab & Muscoskeletal Res Dept, Macclesfield SK10 4TG, Cheshire, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 06期

关键词：

amination; aryl halides; substituent effects;

D O I：

10.1016/S0040-4039(98)02570-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Morpholine substitution in fluorobenzenes containing a meta-substituted electron withdrawing group proceeds in DMSO at 100 degrees C over 60 h to give meta-substitution products (by fluoride ion displacement) in pure isolated yields of 19-98%. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1219 / 1222

页数：4

共 8 条

[1]

[Anonymous], 1991, NUCLEOPHILIC AROMATI

[2] SYNTHESIS OF SOME N-CARBOXYLIC ACID-DERIVATIVES OF 3-PHENOXYPYRROLIDINES, 4-PHENOXYPIPERIDINES, AND 3-PHENOXYNORTROPANES WITH MUSCLE RELAXANT AND ANTICONVULSANT ACTIVITIES [J].