The bacterial outer membrane as a drug barrier

被引：310

作者：

Hancock, REW

机构：

[1] Dept of Microbiology, University of British Columbia, Vancouver, BC

来源：

TRENDS IN MICROBIOLOGY | 1997年 / 5卷 / 01期

关键词：

D O I：

10.1016/S0966-842X(97)81773-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The outer membranes of Gram-negative bacteria constitute a semi-permeable barrier, as indicated by the corresponding alterations in outer membrane permeability and in antibiotic susceptibility resulting from mutation or polycation action. Restricted outer membrane permeability works in synergy with co-determinant resistance mechanisms, such as the periplasmic enzyme beta-lactamase or active efflux mechanisms, bringing about antibiotic resistance.

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页码：37 / 42

页数：6

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