Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors

被引:205
作者
Damsky, CH [1 ]
Fisher, SJ [1 ]
机构
[1] Univ Calif San Francisco, Dept Stomatol, San Francisco, CA 94143 USA
关键词
D O I
10.1016/S0955-0674(98)80043-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
During early development, a subset of fetal (placental) cytotrophoblasts exhibits tumor-like behavior and invades the uterus. To access a supply of maternal blood, they invade arterioles and form heterotypic interactions with, and replace, resident maternal endothelium, creating a hybrid uterine vasculature. Recently, it has become clear that invading cytotrophoblasts transform their adhesion receptor phenotype to resemble the endothelial cells they replace. Furthermore, they express vasculogenic factors and receptors. Is this a form of vasculogenesis?
引用
收藏
页码:660 / 666
页数:7
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