Chronic systemic pesticide exposure reproduces features of Parkinson's disease

被引：2796

作者：

Betarbet, R ^{[1
]}

Sherer, TB ^{[1
]}

MacKenzie, G ^{[1
]}

Garcia-Osuna, M ^{[1
]}

Panov, AV ^{[1
]}

Greenamyre, JT ^{[1
]}

机构：

[1] Emory Univ, Dept Neurol, Atlanta, GA 30322 USA

来源：

NATURE NEUROSCIENCE | 2000年 / 3卷 / 12期

关键词：

D O I：

10.1038/81834

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The cause of Parkinson's disease (PD) is unknown, but epidemiological studies suggest an association with pesticides and other environmental toxins, and biochemical studies implicate a systemic defect in mitochondrial complex I. We report that chronic, systemic inhibition of complex I by the lipophilic pesticide, rotenone, causes highly selective nigrostriatal dopaminergic degeneration that is associated behaviorally with hypokinesia and rigidity. Nigral neurons in rotenone-treated rats accumulate fibrillar cytoplasmic inclusions that contain ubiquitin and alpha -synuclein. These results indicate that chronic exposure to a common pesticide can reproduce the anatomical, neurochemical, behavioral and neuropathological features of PD.

引用

页码：1301 / 1306

页数：6

共 41 条

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