Regulation of GATA gene expression during vertebrate development

被引：99

作者：

Burch, JBE ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Program Cell & Dev Biol, Philadelphia, PA 19111 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2005年 / 16卷 / 01期

关键词：

GATA; enhancers;

D O I：

10.1016/j.semcdb.2004.10.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

GATA factors regulate critical events in hematopoietic lineages (GATA-1/2/3), the heart and gut (GATA-4/5/6) and various other tissues. Transgenic approaches have revealed that GATA genes are regulated in a modular fashion by sets of enhancers that govern distinct temporal and/or spatial facets of the overall expression patterns. Efforts are underway to resolve how these GATA gene enhancers are themselves regulated in order to elucidate the genetic and molecular hierarchies that govern GATA expression in particular developmental contexts. These enhancers also afford a raft of tools that can be used to selectively perturb and probe various developmental events in transgenic animals. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：71 / 81

页数：11

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