Retinoids run rampant: Multiple roles during spinal cord and motor neuron development

被引:51
作者
Appel, B [1 ]
Eisen, JS
机构
[1] Vanderbilt Univ, Dept Biol Sci, Nashville, TN 37235 USA
[2] Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA
关键词
TRANSCRIPTIONAL CODES; PRIMARY NEUROGENESIS; CHICK-EMBRYO; ACID; IDENTITY; DIFFERENTIATION; FGF; SPECIFICATION; SIGNALS;
D O I
10.1016/S0896-6273(03)00688-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Learning how the incredible diversity of neurons in the vertebrate central nervous system (CNS) is generated is a central focus of developmental neuroscience. Three studies in the September 25, 2003, issue of Neuron bring us closer to this goal by revealing how the interplay between Fibroblast Growth Factor (FGF), retinoic acid (RA), and Sonic hedgehog (Shh) signaling regulate progression of spinal cord progenitor cells through various phases of development and specify particular types of spinal motor neurons (MNs).
引用
收藏
页码:461 / 464
页数:4
相关论文
共 17 条
[1]   Hindbrain patterning revisited: timing and effects of retinoic acid signalling [J].
Begemann, G ;
Meyer, A .
BIOESSAYS, 2001, 23 (11) :981-986
[2]  
Diez del Corral R, 2003, NEURON, V40, P65
[3]  
Diez del Corral R, 2002, DEVELOPMENT, V129, P1681
[4]  
DUIDATO S, 2003, DEVELOPMENT, V130, P2981
[5]   DETERMINATION OF PRIMARY MOTONEURON IDENTITY IN DEVELOPING ZEBRAFISH EMBRYOS [J].
EISEN, JS .
SCIENCE, 1991, 252 (5005) :569-572
[6]  
Franco PG, 1999, DEVELOPMENT, V126, P4257
[7]   Patterning of motor neurons by retinoic acid in the chick embryo hindbrain in vitro [J].
Guidato, S ;
Barrett, C ;
Guthrie, S .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2003, 23 (01) :81-95
[8]   Neuronal specification in the spinal cord: Inductive signals and transcriptional codes [J].
Jessell, TM .
NATURE REVIEWS GENETICS, 2000, 1 (01) :20-29
[9]   Assigning the positional identity of spinal motor neurons: Rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoids [J].
Liu, JP ;
Laufer, E ;
Jessell, TM .
NEURON, 2001, 32 (06) :997-1012
[10]  
Mathis L, 2000, DEVELOPMENT, V127, P1277