Membrane proteins with immunoglobulin-like domains - a master superfamily of interaction molecules

被引：199

作者：

Barclay, AN ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

SEMINARS IN IMMUNOLOGY | 2003年 / 15卷 / 04期

关键词：

domain; immunoglobulin-like; interaction; membrane; protein; CELL-ADHESION MOLECULES; CRYSTAL-STRUCTURE; IMMUNOLOGICAL SYNAPSE; RECEPTOR; SURFACE; COMPLEX; LIGAND; RECOGNITION; GLYCOPROTEIN; EXPRESSION;

D O I：

10.1016/S1044-5323(03)00047-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent genomic analysis has shown that proteins with immunoglobulin superfamily (IgSF) domains are extremely abundant and their number has increased markedly in evolution correlating with the development of the adaptive immune system. The lgSF domain is particularly good at being recognised and is involved in many different kinds of interactions. Thus, analysis of the properties of these domains can act as a paradigm for thinking about the roles of newly identified gene products. This review summarises the identification, function and properties of IgSF domains including, their size, variety of interactions, their strength of binding, role of glycosylation and organisation with other proteins. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：215 / 223

页数：9

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