How do cytotoxic lymphocytes kill their targets?

被引：310

作者：

Shresta, S

Pham, CTN

Thomas, DA

Graubert, TA

Ley, TJ ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, Div Bone Marrow Transplantat & Stem Cell Biol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(98)80227-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8+ cytotoxic lymphocytes, natural killer cells and lymphokine-activated killer cells depend primarily on the perforin/granzyme system to kill their targets, while CD4+ T cells utilize Fas and other mechanisms to induce cell death. The molecular mechanisms used by these pathways to induce target cell apoptosis may converge on common death substrates.

引用

收藏

页码：581 / 587

页数：7

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