Membrane protein structure: Prediction versus reality

被引:178
作者
Elofsson, Arne [1 ]
von Heijne, Gunnar [1 ]
机构
[1] Stockholm Univ, Dept Biochem & Biophys, Cte Biomembrane Res, Stockholm Bioinformat Ctr, SE-10691 Stockholm, Sweden
关键词
bioinformatics; membrane protein structure prediction; topology;
D O I
10.1146/annurev.biochem.76.052705.163539
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Since high-resolution structural data are still scarce, different kinds of theoretical structure prediction algorithms are of major importance in membrane protein biochemistry. But how well do the current prediction methods perform? Which structural features can be predicted and which cannot? And what can we expect in the next few years?.
引用
收藏
页码:125 / 140
页数:16
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