The conducting form of gramicidin A is a right handed double-stranded double helix

被引：112

作者：

Burkhart, BM ^{[1
]}

Li, N ^{[1
]}

Langs, DA ^{[1
]}

Pangborn, WA ^{[1
]}

Duax, WL ^{[1
]}

机构：

[1] Hauptman Woodward Med Res Inst Inc, Dept Mol Biophys, Buffalo, NY 14203 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 22期

关键词：

D O I：

10.1073/pnas.95.22.12950

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The linear pentadecapeptide antibiotic, gramicidin D, is a naturally occurring product of Bacillus brevis known to form ion channels in synthetic and natural membranes. The x-ray crystal structures of the right-handed double-stranded double-helical dimers (DSDHR) reported here agree with N-15-NMR and CD data on the functional gramicidin D channel in lipid bilayers. These structures demonstrate single-file ion transfer through the channels. The results also indicate that previous crystal structure reports of a left-handed double-stranded double-helical dimer in complex with Cs+ and K+ salts may be in error and that our evidence points to the DSDHR as the major conformer responsible for ion transport in membranes.

引用

页码：12950 / 12955

页数：6

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