Calcium signalling: Dynamics, homeostasis and remodelling

被引：4385

作者：

Berridge, MJ ^{[1
]}

Bootman, MD ^{[1
]}

Roderick, HL ^{[1
]}

机构：

[1] Babraham Inst, Mol Signalling Lab, Cambridge CB2 4AT, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 07期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/nrm1155

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ca2+ is a highly versatile intracellular signal that operates over a wide temporal range to regulate many different cellular processes. An extensive Ca2+-signalling toolkit is used to assemble signalling systems with very different spatial and temporal dynamics. Rapid highly localized Ca2+ spikes regulate fast responses, whereas slower responses are controlled by repetitive global Ca2+ transients or intracellular Ca2+ waves. Ca2+ has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.

引用

页码：517 / 529

页数：13

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