Two patients walk into a clinic ... a genomics perspective on the future of schizophrenia

被引：9

作者：

Corvin, Aiden P. ^{[1
,2
]}

机构：

[1] Trinity Coll Dublin, Neuropsychiat Genet Res Grp, Inst Mol Med, Dublin 2, Ireland

[2] Trinity Coll Dublin, Dept Psychiat, Dublin 2, Ireland

来源：

BMC BIOLOGY | 2011年 / 9卷

关键词：

COPY NUMBER VARIANTS; COMMON VARIANTS; WIDE ASSOCIATION; CONFERRING RISK; PATHWAYS; MODELS; LOCI;

D O I：

10.1186/1741-7007-9-77

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Progress is being made in schizophrenia genomics, suggesting that this complex brain disorder involves rare, moderate to high-risk mutations and the cumulative impact of small genetic effects, coupled with environmental factors. The genetic heterogeneity underlying schizophrenia and the overlap with other neurodevelopmental disorders suggest that it will not continue to be viewed as a single disease. This has radical implications for clinical practice, as diagnosis and treatment will be guided by molecular etiology rather than clinical diagnostic criteria.

引用

页数：8

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