Host-Gut Microbiota Metabolic Interactions

被引：3801

作者：

Nicholson, Jeremy K. ^{[1
]}

Holmes, Elaine ^{[1
]}

Kinross, James ^{[1
]}

Burcelin, Remy ^{[2
,3
]}

Gibson, Glenn ^{[4
]}

Jia, Wei ^{[5
]}

Pettersson, Sven ^{[6
,7
,8
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Surg & Canc, London SW7 2AZ, England

[2] INSERM, U1048, F-31432 Toulouse, France

[3] Hop Rangueil, Inst Malad Metab & Cardiovasc I2MC, F-31432 Toulouse, France

[4] Univ Reading, Dept Food & Nutr Sci, Reading, Berks, England

[5] Univ N Carolina Greensboro, Dept Nutr, Kannapolis, NC 28081 USA

[6] Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, S-11777 Stockholm, Sweden

[7] Nanyang Technol Univ, Sch Biol Sci, Singapore 169610, Singapore

[8] Natl Canc Ctr, Singapore 169610, Singapore

来源：

SCIENCE | 2012年 / 336卷 / 6086期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

DIET-INDUCED OBESITY; CHAIN FATTY-ACIDS; HEALTH; MODULATION; MICROFLORA; MICE; INFLAMMATION; FERMENTATION; TRYPTOPHAN; ADAPTATION;

D O I：

10.1126/science.1223813

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.

引用

收藏

页码：1262 / 1267

页数：6

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