Activation of inflammation and coagulation after infusion of C-reactive protein in humans

被引：209

作者：

Bisoendial, RJ

Kastelein, JJP

Levels, JHM

Zwaginga, JJ

van den Bogaard, B

Reitsma, PH

Meijers, JCM

Hartman, D

Levi, M

Stroes, ESG

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Hematol, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Expt Med, NL-1105 AZ Amsterdam, Netherlands

[4] Pfizer Global Res & Dev, Ann Arbor, MI USA

来源：

CIRCULATION RESEARCH | 2005年 / 96卷 / 07期

关键词：

Atherosclerosis; Endothelium; Inflammation; Thrombosis;

D O I：

10.1161/01.RES.0000163015.67711.AB

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

C-reactive protein (CRP) has been postulated to play a causal part in atherosclerosis and its acute complications. We assessed the effects of CRP-infusion on coagulation and inflammatory pathways to determine its role in atherothrombotic disease. Seven male volunteers received an infusion on two occasions, containing 1.25 mg/kg recombinant human CRP (rhCRP) or diluent, respectively. CRP-concentrations rose after rhCRP-infusion from 1.9 (0.3 to 8.5) to 23.9 (20.5 to 28.1) mg/L, and subsequently both inflammation and coagulation were activated. This sequence of events suggests that CRP is not only a well known marker of cardiovascular disease, but is also probably a mediator of atherothrombotic disease.

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收藏

页码：714 / 716

页数：3

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