Blocking insulin-like growth factor-I receptor as a strategy for targeting cancer

被引：118

作者：

Hofmann, F ^{[1
]}

García-Echeverría, C ^{[1
]}

机构：

[1] Novartis Inst Biomed Res, Basel, Switzerland

来源：

DRUG DISCOVERY TODAY | 2005年 / 10卷 / 15期

关键词：

D O I：

10.1016/S1359-6446(05)03512-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Clear links between cancer and cellular signaling triggered by the insulin-like growth factor-I (IGF-I) receptor (IGF-IR) and its cognate ligands (IGF-I and IGF-II) have been reported throughout the past two decades. Experimental results suggest that the pharmaceutical targeting of this signaling pathway could be beneficial for the treatment of cancer. Here, more recent advances towards potentially clinically viable strategies to interfere with the function of IGF-IR will be discussed.

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页码：1041 / 1047

页数：7

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