RNA interference - The short answer

被引：72

作者：

Bass, BL

机构：

[1] Univ Utah, Dept Biochem, Salt Lake City, UT 84132 USA

[2] Univ Utah, Howard Hughes Med Inst, Salt Lake City, UT 84132 USA

来源：

NATURE | 2001年 / 411卷 / 6836期

关键词：

D O I：

10.1038/35078175

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

One way of seeing what a gene does is to block its messenger RNA and note the effects. New work should make the approach more broadly applicable.

引用

页码：428 / 429

页数：2

共 14 条

[1] Genome-wide RNAi [J].

Barstead, R .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2001, 5 (01) :63-66

[2] Role for a bidentate ribonuclease in the initiation step of RNA interference [J].

Bernstein, E ;

Caudy, AA ;

Hammond, SM ;

Hannon, GJ .

NATURE, 2001, 409 (6818) :363-366

[3] dsRNA-mediated gene silencing in cultured Drosophila cells:: a tissue culture model for the analysis of RNA interference [J].

Caplen, NJ ;

Fleenor, J ;

Fire, A ;

Morgan, RA .

GENE, 2000, 252 (1-2) :95-105

[4] RNA interference is mediated by 21-and 22-nucleotide RNAs [J].

Elbashir, SM ;

Lendeckel, W ;

Tuschl, T .

GENES & DEVELOPMENT, 2001, 15 (02) :188-200

[5] Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells [J].

Elbashir, SM ;

Harborth, J ;

Lendeckel, W ;

Yalcin, A ;

Weber, K ;

Tuschl, T .

NATURE, 2001, 411 (6836) :494-498

[6] Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans [J].

Fire, A ;

Xu, SQ ;

Montgomery, MK ;

Kostas, SA ;

Driver, SE ;

Mello, CC .

NATURE, 1998, 391 (6669) :806-811

[7]

HUNTER T, 1975, J BIOL CHEM, V250, P409

[8] Functional genomics: The worm scores a knockout [J].

Kim, SK .

CURRENT BIOLOGY, 2001, 11 (03) :R85-R87

[9] INTERACTIONS BETWEEN DOUBLE-STRANDED-RNA REGULATORS AND THE PROTEIN-KINASE DAI [J].

MANCHE, L ;

GREEN, SR ;

SCHMEDT, C ;

MATHEWS, MB .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (11) :5238-5248

[10]

MINKS MA, 1979, J BIOL CHEM, V254, P180

← 1 2 →