Viruses as transneuronal tracers for defining neural circuits

被引：72

作者：

Loewy, AD ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 1998年 / 22卷 / 06期

关键词：

autonomic nervous system; herpesvirus; pseudorabies virus; transneuronal tracing;

D O I：

10.1016/S0149-7634(98)00006-2

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Live viruses can be used as tools to label chains of neurons and thus to define functionally connected CNS circuits. This review summarizes the background and general principles involved in using the viral tracing technology. An attenuated form of a pig herpes virus, known as the Bartha's K strain of pseudorabies virus, has proven to be a useful type of virus for the analysis of CNS systems in the rat. The properties of this virus and the evidence for its specificity in causing trans-synaptic infections is discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：679 / 684

页数：6

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