Toward an integrated genetic and epigenetic approach to Alzheimer's disease

被引：26

作者：

Mill, Jonathan ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, MRC Social, Genet & Dev Psychiat Ctr, London WC2R 2LS, England

来源：

NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 07期

关键词：

Epigenetics; Alzheimer's disease; Genetics; Allele-specific DNA methylation; Postmortem brain samples; ALLELE-SPECIFIC METHYLATION; GENOME-WIDE ASSOCIATION; DNA METHYLATION; EPIGENOMICS;

D O I：

10.1016/j.neurobiolaging.2010.10.021

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Epigenetics is the study of mitotically heritable, but reversible, changes in gene expression brought about principally through alterations in DNA methylation and chromatin structure. The comprehensive review by Mastroeni et al. (Mastroeni, D., Grover, A., Delvaux, E., Whiteside, C., Coleman, P., Rogers, J., 2010. Epigenetic mechanisms in Alzheimer's disease. Neurobiol. Aging, doi: 10.1016/j.neurobiolaging.2010.08.017) in this issue describes mounting evidence for an involvement of epigenetic alterations in the etiology of Alzheimer's disease (AD), highlighting the potential of epigenomic approaches for uncovering novel molecular pathways involved in pathology. Here, we briefly describe some methodological issues related to epigenomic studies using postmortem brain tissue in Alzheimer's disease, and argue for an integrated genetic-epigenetic approach to disease etiology. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1188 / 1191

页数：4

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