Acidic fibroblast growth factor rescues gerbil hippocampal neurons from ischemic apoptotic death

被引：22

作者：

Cuevas, P ^{[1
]}

Carceller, F

Reimers, D

de Tejada, IS

Giménez-Gallego, G

机构：

[1] Hosp Ramon y Cajal, Serv Histol, E-28034 Madrid, Spain

[2] CSIC, Ctr Invest Biol, Madrid, Spain

来源：

NEUROLOGICAL RESEARCH | 1998年 / 20卷 / 03期

关键词：

focal cerebral ischemia; gerbils; fibroblast growth factor; apoptosis;

D O I：

10.1080/01616412.1998.11740518

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neurotrophic factors have been shown to support the survival of injured neurons and promote their recovery. Here, we investigated whether acidic fibroblast growth factor (aFGF) could modify programmed cell death caused by transient forebrain ischemia in the gerbil. The data show that systemic administration of 2.6 mu g aFGF after 5 min ischemia followed by 7 days of brain reperfusion significantly (p < 0.05) reduced the occurrence of apoptotic cell death in CA1 neurons. These data suggest that aFGF would contribute to brain protection after acute stroke.

引用

页码：271 / 274

页数：4

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