Ran-GTP regulates kinetochore attachment in somatic cells

被引：55

作者：

Arnaoutov, A ^{[1
]}

Dasso, M ^{[1
]}

机构：

[1] NICHD, Lab Gene Regulat & Dev, NIH, Bethesda, MD 20892 USA

来源：

CELL CYCLE | 2005年 / 4卷 / 09期

关键词：

Ran; RanGAP1; crm1; kinetochore; microtubule;

D O I：

10.4161/cc.4.9.1979

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Ran GTPase controls multiple mitotic processes in Xenopus egg extracts, including mitotic checkpoints, spindle assembly and post-mitotic nuclear envelope reassembly. We have analyzed Ran's role in somatic cells. We uncovered a novel mitotic role of Ran-GTP, involving the Crm1 nuclear export receptor. This pathway is an important mode of RanGTP function during mitosis in mammalian somatic cells, which mediates the recruitment of the RanGAP1/RanBP2 complex to kinetochores and maintains the microtubule-based fibers connecting kinetochores to spindle poles (k-fibers). Here we discuss potential implications of these findings for normal k-fiber assembly.

引用

页码：1161 / 1165

页数：5

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