Even moderate cigarette smoking influences the pattern of circulating monocytes and the concentration of sICAM-1

被引：70

作者：

Bergmann, S ^{[1
]}

Siekmeier, R ^{[1
]}

Mix, C ^{[1
]}

Jaross, W ^{[1
]}

机构：

[1] Tech Univ Dresden, Univ Klinikum Carl Gustav Carus, Inst Klin Chem & Lab Med, D-01307 Dresden, Germany

来源：

RESPIRATION PHYSIOLOGY | 1998年 / 114卷 / 03期

关键词：

blood; monocytes; moderate smoking; mammals; humans; proteins; ICAM-1; adhesion molecules;

D O I：

10.1016/S0034-5687(98)00098-X

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The pattern of circulating monocyte subtypes and the concentration of the soluble intercellular adhesion molecule-1 (ICAM-1) were compared in middle-aged female moderate smokers and lifetime non-smokers. Total leukocyte and monocyte counts were higher in smokers. The pattern of circulating monocytes of smokers was changed toward lower absolute counts of activated (CD16 +/CD64 +) monocytes and (CD16 +/CD14 +) monocyte-macrophages and higher counts of nonactivated monocytes. The serum concentration of soluble ICAM-1 was significantly higher in smokers than in non-smokers. It is supposed that even moderate cigarette smoking leads to an activation of the circulating monocytes and their increased adhesion to the endothelium. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：269 / 275

页数：7

共 23 条

[1] Cigarette smoking is associated with increased human monocyte adhesion to endothelial cells: Reversibility with oral L-arginine but not vitamin C [J].