Apoptosis - Baiting death inhibitors

被引:23
作者
Nicholson, DW [1 ]
机构
[1] Merck Frosst Ctr Therapeut Res, Pointe Claire, PQ H9R 4P8, Canada
关键词
D O I
10.1038/35065201
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Enzymes called caspases that start the process of programmed cell death can be dangerous if activated at the wrong time. A feat of self-restraint keeps one such caspase under control.
引用
收藏
页码:33 / 34
页数:2
相关论文
共 12 条
[1]   Structural and biochemical basis of apoptotic activation by Smac/DIABLO [J].
Chai, JJ ;
Du, CY ;
Wu, JW ;
Kyin, S ;
Wang, XD ;
Shi, YG .
NATURE, 2000, 406 (6798) :855-862
[2]   Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases [J].
Deveraux, QL ;
Leo, E ;
Stennicke, HR ;
Welsh, K ;
Salvesen, GS ;
Reed, JC .
EMBO JOURNAL, 1999, 18 (19) :5242-5251
[3]   Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition [J].
Du, CY ;
Fang, M ;
Li, YC ;
Li, L ;
Wang, XD .
CELL, 2000, 102 (01) :33-42
[4]   DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9 [J].
Ekert, PG ;
Silke, J ;
Hawkins, CJ ;
Verhagen, AM ;
Vaux, DL .
JOURNAL OF CELL BIOLOGY, 2001, 152 (03) :483-490
[5]   Apoptotic pathways: Paper wraps stone blunts scissors [J].
Green, DR .
CELL, 2000, 102 (01) :1-4
[6]   Identification of XAF1 as an antagonist of XIAP anti-caspase activity [J].
Liston, P ;
Fong, WG ;
Kelly, NL ;
Toji, S ;
Miyazaki, T ;
Conte, D ;
Tamai, K ;
Craig, CG ;
McBurney, MW ;
Korneluk, RG .
NATURE CELL BIOLOGY, 2001, 3 (02) :128-133
[7]   Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain [J].
Liu, ZH ;
Sun, CH ;
Olejniczak, ET ;
Meadows, RP ;
Betz, SF ;
Oost, T ;
Herrmann, J ;
Wu, JC ;
Fesik, SW .
NATURE, 2000, 408 (6815) :1004-1008
[8]   Caspase structure, proteolytic substrates, and function during apoptotic cell death [J].
Nicholson, DW .
CELL DEATH AND DIFFERENTIATION, 1999, 6 (11) :1028-1042
[9]   Cross-talk in cell death signaling [J].
Roy, S ;
Nicholson, DW .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (08) :F21-F25
[10]   A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis [J].
Srinivasula, SM ;
Hegde, R ;
Saleh, A ;
Datta, P ;
Shiozaki, E ;
Chai, JJ ;
Lee, RA ;
Robbins, PD ;
Fernandes-Alnemri, T ;
Shi, YG ;
Alnemri, ES .
NATURE, 2001, 410 (6824) :112-116