Effects of Selective Anxiolytic Afobazole on Active Caspase-3

被引：11

作者：

Antipova, T. A. ^{[1
]}

Sapozhnikova, D. S.

Stepanichev, M. Yu.

Onufriev, M. V.

Gulyaeva, N. V.

Seredenin, S. B.

机构：

[1] Russian Acad Med Sci, Lab Pharmacol Neuroprotect, VV Zakusov Inst Pharmacol, Moscow 109801, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2010年 / 149卷 / 02期

关键词：

afobazole; apoptosis; caspase-3; neuroprotection; APOPTOSIS; NECROSIS; ACTIVATION; ISCHEMIA; DEATH;

D O I：

10.1007/s10517-010-0907-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effects of afobazole on apoptosis through active caspase-3. Afobazole in a final concentration of 10(-8) M inhibits hyperactivation of effector apoptotic caspase-3 in HT-22 cell culture under conditions of glutamate toxicity.

引用

页码：201 / 203

页数：3

共 14 条

[1] AMYLOID-BETA PEPTIDE INDUCES NECROSIS RATHER THAN APOPTOSIS [J].

BEHL, C ;

DAVIS, JB ;

KLIER, FG ;

SCHUBERT, D .

BRAIN RESEARCH, 1994, 645 (1-2) :253-264

[2] Neuroprotective effects of afobazol in experimental cerebral hemorrhage [J].

Galaeva, IP ;

Garibova, TL ;

Voronina, TA ;

Seredenin, SB .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2005, 140 (05) :535-537

[3]

GOMAZKOV OA, 2002, INSULT, V7, P17

[4] Caspase activity is essential for long-term potentiation [J].

Gulyaeva, NV ;

Kudryashov, IE ;

Kudryashova, IV .

JOURNAL OF NEUROSCIENCE RESEARCH, 2003, 73 (06) :853-864

[5]

KERR JFR, 1995, METHOD CELL BIOL, V46, P1

[6]

MIRZOYAN RS, 1996, EKSP KLIN FARMAKOL, V59, P62

[7]

Namura S, 1998, J NEUROSCI, V18, P3659

[8] Caspases: killer proteases [J].

Nicholson, DW ;

Thornberry, NA .

TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (08) :299-306

[9]

Silkina I. V., 2004, Eksperimental'naya i Klinicheskaya Farmakologiya, V67, P9

[10]

Tan SL, 1998, J NEUROCHEM, V71, P95

← 1 2 →