The BioGRID interaction database:: 2008 update

被引：536

作者：

Breitkreutz, Bobby-Joe ^{[1
]}

Stark, Chris ^{[1
]}

Reguly, Teresa ^{[1
]}

Boucher, Lorrie ^{[1
,2
]}

Breitkreutz, Ashton ^{[1
]}

Livstone, Michael ^{[3
]}

Oughtred, Rose ^{[3
]}

Lackner, Daniel H. ^{[4
]}

Bahler, Jurg ^{[4
]}

Wood, Valerie ^{[4
]}

Dolinski, Kara ^{[3
]}

Tyers, Mike ^{[1
,2
]}

机构：

[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[2] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada

[3] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA

[4] Wellcome Trust Sanger Inst, Cambridge, England

来源：

NUCLEIC ACIDS RESEARCH | 2008年 / 36卷

基金：

加拿大健康研究院; 美国国家卫生研究院; 英国惠康基金;

关键词：

D O I：

10.1093/nar/gkm1001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Biological General Repository for Interaction Datasets ( BioGRID) database (http://www.thebiogrid.org) was developed to house and distribute collections of protein and genetic interactions from major model organism species. BioGRID currently contains over 198 000 interactions from six different species, as derived from both high-throughput studies and conventional focused studies. Through comprehensive curation efforts, BioGRID now includes a virtually complete set of interactions reported to date in the primary literature for both the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe. A number of new features have been added to the BioGRID including an improved user interface to display interactions based on different attributes, a mirror site and a dedicated interaction management system to coordinate curation across different locations. The BioGRID provides interaction data with monthly updates to Saccharomyces Genome Database, Flybase and Entrez Gene. Source code for the BioGRID and the linked Osprey network visualization system is now freely available without restriction.

引用

页码：D637 / D640

页数：4

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