Obesity cardiomyopathy: Pathophysiology and evolution of the clinical syndrome

被引:526
作者
Alpert, MA [1 ]
机构
[1] Univ S Alabama, Med Ctr, Coll Med, Div Cardiol, Mobile, AL 36617 USA
关键词
obesity; cardiac morphology; hemodynamics; left ventricular function; congestive heart failure; sleep apnea; obesity hypoventilation syndrome;
D O I
10.1097/00000441-200104000-00003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Obesity produces an increase in total blood volume and cardiac output because of the high metabolic activity of excessive fat. In moderate to severe cases of obesity, this may lead to left ventricular dilation, increased left ventricular wall stress, compensatory (eccentric) left ventricular hypertrophy, and left ventricular diastolic dysfunction. Left ventricular systolic dysfunction may occur if wall stress remains high because of inadequate hypertrophy. Right ventricular structure and function may be similarly affected by the aforementioned morphologic and hemodynamic alterations and by pulmonary hypertension related to the sleep apnea/obesity hypoventilation syndrome. The term obesity cardiomyopathy is applied when these cardiac structural and hemodynamic changes result in congestive heart failure. Obesity cardiomyopathy typically occurs in persons with severe and long-standing obesity. The predominant causes of death in those with obesity cardiomyopathy are progressive congestive heart failure and sudden cardiac death.
引用
收藏
页码:225 / 236
页数:12
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