Cloning of the human SIX1 gene and its assignment to chromosome 14

被引：48

作者：

Boucher, CA

Carey, N

Edwards, YH

Siciliano, MJ

Johnson, KJ

机构：

[1] CHARING CROSS & WESTMINSTER MED SCH,DEPT ANAT,GENET UNIT,LONDON W6 8RF,ENGLAND

[2] UNIV LONDON UNIV COLL,GALTON LAB,MRC,HUMAN BIOCHEM GENET UNIT,LONDON NW1 2HE,ENGLAND

[3] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT MOLEC GENET,HOUSTON,TX 77030

来源：

GENOMICS | 1996年 / 33卷 / 01期

关键词：

D O I：

10.1006/geno.1996.0172

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The recently described murine homeobox genes, Six1 and Six2, which are expressed during development in limb tendons, have also been shown to be expressed in skeletal and smooth muscle, respectively, We have cloned and sequenced a human SIX1 cDNA and shown by Northern blotting that it is expressed in adult skeletal muscle. The cDNA sequence and predicted protein sequence of SIX1 and Six1 are highly homologous, with 98% similarity over the entire predicted amino acid sequence, SIX1 was mapped to human chromosome 14 using a rodent/human somatic cell hybrid panel. (C) 1996 Academic Press, Inc.

引用

页码：140 / 142

页数：3

共 7 条

[1] A NOVEL HOMEODOMAIN-ENCODING GENE IS ASSOCIATED WITH A LARGE CPG ISLAND INTERRUPTED BY THE MYOTONIC-DYSTROPHY UNSTABLE (CTG)(N) REPEAT [J].