Imaging of amyloid-β deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy

被引：381

作者：

Backskai, BJ

Kajdasz, ST

Christie, RH

Carter, C

Games, D

Seubert, P

Schenk, D

Hyman, BT ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Alzheimers Dis Res Lab, Charlestown, MA 02129 USA

[2] Elan Pharmaceut, S San Francisco, CA USA

来源：

NATURE MEDICINE | 2001年 / 7卷 / 03期

关键词：

D O I：

10.1038/85525

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：369 / 372

页数：4

共 14 条

[1] Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease [J].

Bard, F ;

Cannon, C ;

Barbour, R ;

Burke, RL ;

Games, D ;

Grajeda, H ;

Guido, T ;

Hu, K ;

Huang, JP ;

Johnson-Wood, K ;

Khan, K ;

Kholodenko, D ;

Lee, M ;

Lieberburg, I ;

Motter, R ;

Nguyen, M ;

Soriano, F ;

Vasquez, N ;

Weiss, K ;

Welch, B ;

Seubert, P ;

Schenk, D ;

Yednock, T .

NATURE MEDICINE, 2000, 6 (08) :916-919

[2] NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].

BRAAK, H ;

BRAAK, E .

ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259

[3] Alzheimer neuropathologic alterations in aged cognitively normal subjects [J].

Davis, DG ;

Schmitt, FA ;

Wekstein, DR ;

Markesbery, WR .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1999, 58 (04) :376-388

[4] 2-PHOTON LASER SCANNING FLUORESCENCE MICROSCOPY [J].

DENK, W ;

STRICKLER, JH ;

WEBB, WW .

SCIENCE, 1990, 248 (4951) :73-76

[5] ALZHEIMER-TYPE NEUROPATHOLOGY IN TRANSGENIC MICE OVEREXPRESSING V717F BETA-AMYLOID PRECURSOR PROTEIN [J].

GAMES, D ;

ADAMS, D ;

ALESSANDRINI, R ;

BARBOUR, R ;

BERTHELETTE, P ;

BLACKWELL, C ;

CARR, T ;

CLEMENS, J ;

DONALDSON, T ;

GILLESPIE, F ;

GUIDO, T ;

HAGOPIAN, S ;

JOHNSONWOOD, K ;

KHAN, K ;

LEE, M ;

LEIBOWITZ, P ;

LIEBERBURG, I ;

LITTLE, S ;

MASLIAH, E ;

MCCONLOGUE, L ;

MONTOYAZAVALA, M ;

MUCKE, L ;

PAGANINI, L ;

PENNIMAN, E ;

POWER, M ;

SCHENK, D ;

SEUBERT, P ;

SNYDER, B ;

SORIANO, F ;

TAN, H ;

VITALE, J ;

WADSWORTH, S ;

WOLOZIN, B ;

ZHAO, J .

NATURE, 1995, 373 (6514) :523-527

[6]

GomezIsla T, 1996, J NEUROSCI, V16, P4491

[7] KUNITZ PROTEASE INHIBITOR-CONTAINING AMYLOID-BETA PROTEIN-PRECURSOR IMMUNOREACTIVITY IN ALZHEIMERS-DISEASE [J].

HYMAN, BT ;

TANZI, RE ;

MARZLOFF, K ;

BARBOUR, R ;

SCHENK, D .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1992, 51 (01) :76-83

[8]

Irizarry MC, 1997, J NEUROSCI, V17, P7053

[9] Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline [J].

Näslund, J ;

Haroutunian, V ;

Mohs, R ;

Davis, KL ;

Davies, P ;

Greengard, P ;

Buxbaum, JD .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (12) :1571-1577

[10] Immunization with amyloid-β attenuates Alzheimer disease-like pathology in the PDAPP mouse [J].

Schenk, D ;

Barbour, R ;

Dunn, W ;

Gordon, G ;

Grajeda, H ;

Guido, T ;

Hu, K ;

Huang, JP ;

Johnson-Wood, K ;

Khan, K ;

Kholodenko, D ;

Lee, M ;

Liao, ZM ;

Lieberburg, I ;

Motter, R ;

Mutter, L ;

Soriano, F ;

Shopp, G ;

Vasquez, N ;

Vandevert, C ;

Walker, S ;

Wogulis, M ;

Yednock, T ;

Games, D ;

Seubert, P .

NATURE, 1999, 400 (6740) :173-177

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