Alzheimer disease - when and why?

被引:29
作者
Price, DL [1 ]
Sisodia, SS
Borchelt, DR
机构
[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Sch Med, Div Neuropathol, Baltimore, MD 21205 USA
[4] Univ Chicago, Dept Pharmacol & Physiol Sci, Chicago, IL 60637 USA
[5] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
关键词
D O I
10.1038/1196
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
引用
收藏
页码:314 / 316
页数:3
相关论文
共 10 条
[1]   Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition [J].
Bales, KR ;
Verina, T ;
Dodel, RC ;
Du, YS ;
Altstiel, L ;
Bender, M ;
Hyslop, P ;
Johnstone, EM ;
Little, SP ;
Cummins, DJ ;
Piccardo, P ;
Ghetti, B ;
Paul, SM .
NATURE GENETICS, 1997, 17 (03) :263-264
[2]   Alpha-2 macroglobulin is genetically associated with Alzheimer disease [J].
Blacker, D ;
Wilcox, MA ;
Laird, NM ;
Rodes, L ;
Horvath, SM ;
Go, RCP ;
Perry, R ;
Watson, B ;
Bassett, SS ;
McInnis, MG ;
Albert, MS ;
Hyman, BT ;
Tanzi, RE .
NATURE GENETICS, 1998, 19 (04) :357-360
[3]   Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins [J].
Borchelt, DR ;
Ratovitski, T ;
vanLare, J ;
Lee, MK ;
Gonzales, V ;
Jenkins, NA ;
Copeland, NG ;
Price, DL ;
Sisodia, SS .
NEURON, 1997, 19 (04) :939-945
[4]   A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia [J].
Bullido, MJ ;
Artiga, MJ ;
Recuero, M ;
Sastre, I ;
Garcia, MA ;
Aldudo, J ;
Lendon, C ;
Han, SW ;
Morris, JC ;
Frank, A ;
Vázquez, J ;
Goate, A ;
Valdivieso, F .
NATURE GENETICS, 1998, 18 (01) :69-71
[5]   Protein topology of presenilin 1 [J].
Doan, A ;
Thinakaran, G ;
Borchelt, DR ;
Slunt, HH ;
Ratovitsky, T ;
Podlisny, M ;
Selkoe, DJ ;
Seeger, M ;
Gandy, SE ;
Price, DL ;
Sisodia, SS .
NEURON, 1996, 17 (05) :1023-1030
[6]   Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans [J].
Goedert, M ;
Jakes, R ;
Spillantini, MG ;
Hasegawa, M ;
Smith, MJ ;
Crowther, RA .
NATURE, 1996, 383 (6600) :550-553
[7]   APOE genotype predicts when -: not whether -: one is predisposed to develop Alzheimer disease [J].
Meyer, MR ;
Tschanz, JT ;
Norton, MC ;
Welsh-Bohmer, KA ;
Steffens, DC ;
Wyse, BW ;
Breitner, JCS .
NATURE GENETICS, 1998, 19 (04) :321-322
[8]   Complete genomic screen in late-onset familial Alzheimer disease - Evidence for a new locus on chromosome 12 [J].
PericakVance, MA ;
Bass, MP ;
Yamaoka, LH ;
Gaskell, PC ;
Scott, WK ;
Terwedow, HA ;
Menold, MM ;
Conneally, PM ;
Small, GW ;
Vance, JM ;
Saunders, AM ;
Roses, AD ;
Haines, JL .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (15) :1237-1241
[9]   Mutant genes in familial Alzheimer's disease and transgenic models [J].
Price, DL ;
Sisodia, SS .
ANNUAL REVIEW OF NEUROSCIENCE, 1998, 21 :479-505
[10]  
STGEORGEHYSLOP PH, 1998, NEUROPATHOLOGY DEMEN, P106