Absence of rearrangements in the BRCA2 gene in human cancers

被引：6

作者：

Chin, SF

Wang, Q

Puisieux, A

Caldas, C

机构：

[1] Univ Cambridge, CRC, Dept Oncol, Cambridge CB2 2XY, England

[2] Addenbrookes Hosp, Cambridge Inst Med Res, Wellcome Trust Ctr Mol Mech Dis, Cambridge CB2 2XY, England

[3] Ctr Leon Berard, INSERM, U453, F-69373 Lyon, France

来源：

BRITISH JOURNAL OF CANCER | 2001年 / 84卷 / 02期

关键词：

BRCA2; southern blot; human cancers; rearrangement; deletion;

D O I：

10.1054/bjoc.2000.1577

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mutations of BRCA2 in sporadic breast and ovarian carcinomas are exceedingly rare. This led to the suggestion that large genomic rearrangements could be involved. We performed Southern blots in genomic DNA from 130 primary breast cancers and 83 cancer cell lines (breast, ovarian. pancreatic and small cell lung carcinomas) and found no genomic rearrangements. These results suggest that a gene other than BRCA2 is the target of the frequent 13q12.3 allelic deletions in human cancers. (C) 2001 Cancer Research Campaign.

引用

页码：193 / 195

页数：3

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