Histological and temporal characteristics of nigral transneuronal degeneration after striatal injury

被引：35

作者：

DeGiorgio, LA

Dibinis, C

Milner, TA

Saji, M

Volpe, BT

机构：

[1] Cornell Univ, Sch Med, Burke Med Res Inst, Dept Neurol & Neurosci, White Plains, NY 10605 USA

[2] Cornell Univ, Sch Med, Dept Neurol & Neurosci, New York, NY 10021 USA

[3] Tottori Univ, Sch Med, Dept Neurobiol, Yonago, Tottori 653, Japan

来源：

BRAIN RESEARCH | 1998年 / 795卷 / 1-2期

关键词：

transneuronal degeneration; basal ganglia; excitotoxicity; substantia nigra reticulata; programmed cell death;

D O I：

10.1016/S0006-8993(98)00247-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurotoxic injury of the caudate-putamen and lateral globus pallidus unilaterally initiated transneuronal degeneration of neurons in the ipsilateral substantia nigra reticulata (SNR). Quantification of SNR neurons using unbiased stereology demonstrated that neuron loss began 4 days after the initial striatal lesion, followed by significant loss (50%) at 6 days and a plateau at 8 days. Analysis at the light and ultrastructural levels revealed morphological changes consistent with a type of programmed cell death. These temporal and histological results refine an in vivo model in which to explore mechanisms of delayed neuronal degeneration. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 9

页数：9

共 46 条

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