Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses

被引：1131

作者：

Hatta, M

Gao, P

Halfmann, P

Kawaoka, Y

机构：

[1] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA

[2] Univ Tokyo, Inst Med Sci, Minato Ku, Tokyo 1088639, Japan

来源：

SCIENCE | 2001年 / 293卷 / 5536期

关键词：

D O I：

10.1126/science.1062882

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.

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页码：1840 / 1842

页数：3

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