Polymorphisms in inflammatory cytokines and Fcγ receptors in childhood chronic immune thrombocytopenic purpura:: a pilot study

被引：76

作者：

Foster, CB

Zhu, SX

Erichsen, HC

Lehrnbecher, T

Hart, ES

Choi, E

Stein, S

Smith, MW

Steinberg, SM

Imbach, P

Kühne, T

Chanock, SJ

机构：

[1] NCI, Ctr Adv Technol, Pediat Oncol Branch, Immunocompromised Host Sect,NIH, Gaithersburg, MD 20877 USA

[2] NCI, Sci Applicat Int Corp, Frederick, MD 21701 USA

[3] NCI, Biostat & Data Management Sect, NIH, Bethesda, MD 20892 USA

[4] Univ Basel, Basel, Switzerland

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2001年 / 113卷 / 03期

关键词：

cytokines; Fc gamma receptors; chronic immune thrombocytopenic purpura; genetic associations;

D O I：

10.1046/j.1365-2141.2001.02807.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inflammatory cytokines and low-affinity Fc gamma receptor (Fc gammaR) polymorphisms were investigated in 37 children with chronic immune thrombocytopenic purpura (cITP) and 218 controls. Genotype analysis included common variants in the regulatory regions of cytokines, TNF, LTA, IL1RN, IL1A, IL1B, IL4, IL6 and IL10, and structural variants of the low affinity Fc gamma Rs, FCGR2A, FCGR3A and FCGR3B. Associations were observed for TNF (P = 0.0032), LTA (P = 0.019), FCGR3A (P = 0.038) and FCGR3B (P = 0.0034). Two combinations of genotypes (TNF and FCGR3A; P = 0.0003, and LTA and FCGR3B; P = 0.011) were significantly associated with cITP, These results provide preliminary evidence that variant genotypes of Fc gamma Rs and cytokines contribute to cITP pathogenesis.

引用

页码：596 / 599

页数：4

共 16 条

[1]

BREDIUS RGM, 1994, IMMUNOLOGY, V83, P624

[2]

Foster CB, 2000, BLOOD, V96, P2562

[3]

IMBACH PA, 1994, CLIN EXP IMMUNOL, V97, P25

[4] ASSOCIATION OF HLA-DRW2 WITH AUTO-IMMUNE THROMBOCYTOPENIC PURPURA [J].