Microbiota-stimulated immune mechanisms to maintain gut homeostasis

被引：167

作者：

Chung, Hachung ^{[1
]}

Kasper, Dennis Lee ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Channing Lab, Boston, MA 02115 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 04期

关键词：

SEGMENTED FILAMENTOUS BACTERIA; REGULATORY T-CELLS; GENOME-WIDE ASSOCIATION; DENDRITIC CELLS; SYMBIOTIC BACTERIA; KEY ROLE; GERM-FREE; RESPONSES; COLITIS; FLORA;

D O I：

10.1016/j.coi.2010.06.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent years there has been an explosion of interest to identify microbial inhabitants of human and understand their beneficial role in health. In the gut, a symbiotic host-microbial interaction has coevolved as bacteria make essential contributions to human metabolism and bacteria in turn benefits from the nutrient-rich niche in the intestine. To maintain host-microbe coexistence, the host must protect itself against microbial invasion, injury, and overreactions to foreign food antigens, and gut microbes need protection against competing microbes and the host immune system. Perturbation of this homeostatic coexistence has been strongly associated with human disease. This review discusses how gut bacteria regulate host innate and adaptive immunity, with emphasis on how this regulation contributes to host-microbe homeostasis in the gut.

引用

页码：455 / 460

页数：6

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