Opportunities and strategies for introducing pharmacogenetics into early drug development

被引：9

作者：

Chamberlain, JC ^{[1
]}

Joubert, PH ^{[1
]}

机构：

[1] Roche Prod Ltd, Welwyn Garden City AL7 3AY, Herts, England

来源：

DRUG DISCOVERY TODAY | 2001年 / 6卷 / 11期

关键词：

D O I：

10.1016/S1359-6446(01)01777-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Following the publication of the first draft of the human genome, this is a good time to re-analyse the potential contribution of genomics to drug development. Pharma, biotech and academia are already queuing up to deliver novel data impinging on every aspect of medicine and we can foresee a five-year scenario in which every new drug with a known mode of action will have a target gene sequence in the public domain. As such, current development strategies must ultimately be capable of anticipating and addressing genetic issues. This article attempts to position recent developments in genomics from an industrial perspective.

引用

页码：569 / 574

页数：6

共 31 条

[1]

Alves S, 1999, PHARMACOGENETICS, V9, P257

[2] Thiopurine methyltransferase alleles in British and Ghanaian populations [J].

Ameyaw, MM ;

Collie-Duguid, ESR ;

Powrie, RH ;

Ofori-Adjei, D ;

McLeod, HL .

HUMAN MOLECULAR GENETICS, 1999, 8 (02) :367-370

[3] Genetic diversity and disease susceptibility [J].

Bodmer, WF .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1997, 352 (1357) :1045-1050

[4] Testing drug response in the presence of genetic information: sampling issues for clinical trials [J].

Cardon, LR ;

Idury, RM ;

Harris, TJR ;

Witte, JS ;

Elston, RC .

PHARMACOGENETICS, 2000, 10 (06) :503-510

[5]

COUGH AC, 1990, NATURE, V347, P773

[6]

DEMORAIS SMF, 1994, J BIOL CHEM, V269, P15419

[7]

Estabrook R, 1999, Mol Aspects Med, V20, P5

[8] Clinical trials in the genomic era: Effects of protective genotypes on sample size and duration of trial [J].

Fijal, BA ;

Hall, JM ;

Witte, JS .

CONTROLLED CLINICAL TRIALS, 2000, 21 (01) :7-20

[9] Will genetics really revolutionize the drug discovery process? [J].

Gelbert, LM ;

Gregg, RE .

CURRENT OPINION IN BIOTECHNOLOGY, 1997, 8 (06) :669-674

[10] Single nucleotide polymorphisms as tools in human genetics [J].

Gray, IC ;

Campbell, DA ;

Spurr, NK .

HUMAN MOLECULAR GENETICS, 2000, 9 (16) :2403-2408

← 1 2 3 4 →