Activation of interferon-gamma inducing factor mediated by interleukin-1 beta converting enzyme

被引：1027

作者：

Gu, Y

Kuida, K

Tsutsui, H

Ku, G

Hsiao, K

Fleming, MA

Hayashi, N

Higashino, K

Okamura, H

Nakanishi, K

Kurimoto, M

Tanimoto, T

Flavell, RA

Sato, V

Harding, MW

Livingston, DJ

Su, MSS

机构：

[1] TOKYO METROPOLITAN INST MED SCI,TOKYO 113,JAPAN

[2] HYOGO MED UNIV,NISHINOMIYA,HYOGO,JAPAN

[3] HAYASHIBARA CO INC,HAYASHIBARA BIOCHEM LABS,OKAYAMA,JAPAN

[4] YALE UNIV,SCH MED,HOWARD HUGHES MED INST,NEW HAVEN,CT 06510

来源：

SCIENCE | 1997年 / 275卷 / 5297期

关键词：

D O I：

10.1126/science.275.5297.206

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The interleukin-1 beta (IL-1 beta) converting enzyme (ICE) processes the inactive IL-IP precursor to the proinflammatory cytokine. ICE was also shown to cleave the precursor of interferon-gamma inducing factor (IGIF) at the authentic processing site with high efficiency, thereby activating IGIF and facilitating its export. Lipopolysaccharide-activated ICE-deficient (ICE(-/-)) Kupffer cells synthesized the IGIF precursor but failed to process it into the active form. Interferon-gamma and IGIF were diminished in the sera of ICE(-/-) mice exposed to Propionibacterium acnes and lipopolysaccharide. The lack of multiple proinflammatory cytokines in ICE(-/-) mice may account for their protection from septic shock.

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页码：206 / 209

页数：4

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