Maternal occupational exposure to extremely low frequency magnetic fields during pregnancy and childhood leukemia

被引:48
作者
Infante-Rivard, C
Deadman, JE
机构
[1] McGill Univ, Fac Med, Joint Dept Epidemiol, Montreal, PQ H3A 1A3, Canada
[2] McGill Univ, Fac Med, Dept Biostat, Montreal, PQ H3A 1A3, Canada
[3] McGill Univ, Fac Med, Dept Occupat Hlth, Montreal, PQ H3A 1A3, Canada
[4] CHU Mere Enfant, Hop St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada
关键词
acute lymphoblastic leukemia; electromagnetic fields; child; maternal exposure; occupational exposure;
D O I
10.1097/01.ede.0000078421.60231.bc
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: Pregnancy is a target period for events that could induce childhood leukemia. There has been little attention to possible effects of maternal occupational exposure to extremely low frequency magnetic fields (ELF-MF) during pregnancy. Methods: We conducted a population-based, case-control study of 491 incident cases of acute lymphoblastic leukemia in children 0-9 years of age, matched on age and sex to 491 healthy controls. Cases were diagnosed in the Province of Quebec between 1980 and 1993. Mothers were interviewed to obtain detailed prenatal occupational history; individual exposure to ELF-MF was estimated based on a method we recently developed. We used 3 metrics for analyzing exposure: cumulative, average and maximum levels. Analyses were carried out among all study women and among working women only. Results: Comparing the highest 10% of exposed mothers to the others, the risk of leukemia among offspring was moderately increased by using any metric, in all women and among working women only. The highest odds ratio of 2.5 (95% confidence interval = 1.2-5.0) was found for maximum exposure attained in an occupation (greater than or equal to0.4 microtesla). Conclusions: Our results are compatible with an increased risk of childhood leukemia among children whose mothers were exposed to the highest occupational levels of ELF-MF during pregnancy.
引用
收藏
页码:437 / 441
页数:5
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