Defining the Extent of Irreversible Brain Ischemia Using Perfusion Computed Tomography

被引：87

作者：

Bivard, Andrew ^{[3
]}

McElduff, Patrick ^{[3
]}

Spratt, Neil ^{[3
]}

Levi, Christopher ^{[1
,2
]}

Parsons, Mark ^{[1
,2
]}

机构：

[1] Univ Newcastle, Dept Neurol, Newcastle, NSW 2310, Australia

[2] Univ Newcastle, Hunter Med Res Inst, Newcastle, NSW 2310, Australia

[3] Univ Newcastle, John Hunter Hosp, Newcastle, NSW 2300, Australia

来源：

CEREBROVASCULAR DISEASES | 2011年 / 31卷 / 03期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Acute stroke; Infarct core; Perfusion computed tomography; MRI; INFARCT CORE; ACUTE STROKE; BLOOD-FLOW; DIFFUSION; PENUMBRA; CT; IDENTIFICATION; THRESHOLDS; RISK;

D O I：

10.1159/000321897

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Perfusion computed tomography (PCT) shows promise in acute stroke assessment. However, the accuracy of CT perfusion thresholds in defining the acute infarct core remains uncertain. Method: Concurrent PCT and MRI-DWI performed 3-6 h after symptoms onset were assessed in 57 ischemic stroke patients. PCT was compared to DWI images to define the infarct core using a pixel-based receiver operating characteristic curve analysis to calculate the area under the curve (AUC) for thresholds from PCT maps that were coregistered with the DWI slice location. Results: A relative cerebral blood flow (CBF) of 45% of the contralateral hemisphere was found to be the most accurate threshold for describing the infarct core (AUC 0.788), and it was also by far the most frequent threshold with the highest AUC across patients. Conclusion: CBF thresholds on PCT define the acute infarct core more accurately than do other PCT thresholds, including a cerebral blood volume of 2 ml/100 g. Copyright (C) 2010 S. Karger AG, Basel

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页码：238 / 245

页数：8

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