Diverse Roles of Macrophages in Atherosclerosis: From Inflammatory Biology to Biomarker Discovery

被引：159

作者：

Gui, Ting ^{[1
]}

Shimokado, Aiko ^{[1
,2
]}

Sun, Yujing ^{[1
]}

Akasaka, Takashi ^{[2
]}

Muragaki, Yasuteru ^{[1
]}

机构：

[1] Wakayama Med Univ, Dept Pathol 1, Sch Med, Wakayama 6410012, Japan

[2] Wakayama Med Univ, Dept Cardiovasc Med, Wakayama 6410012, Japan

来源：

MEDIATORS OF INFLAMMATION | 2012年 / 2012卷

关键词：

NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; LOW-DENSITY-LIPOPROTEIN; MIGRATION INHIBITORY FACTOR; ENDOPLASMIC-RETICULUM STRESS; SCAVENGER RECEPTOR CD36; FOAM CELL-FORMATION; IMMUNE-RESPONSE; TGF-BETA; ACCELERATED ATHEROSCLEROSIS;

D O I：

10.1155/2012/693083

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cardiovascular disease, a leading cause of mortality in developed countries, is mainly caused by atherosclerosis, a chronic inflammatory disease. Macrophages, which differentiate from monocytes that are recruited from the blood, account for the majority of leukocytes in atherosclerotic plaques. Apoptosis and the suppressed clearance of apoptotic macrophages (efferocytosis) are associated with vulnerable plaques that are prone to rupture, leading to thrombosis. Based on the central functions of macrophages in atherogenesis, cytokines, chemokines, enzymes, or microRNAs related to or produced by macrophages have become important clinical prognostic or diagnostic biomarkers. This paper discusses the impact of monocyte-derived macrophages in early atherogenesis and advanced disease. The role and possible future development of macrophage inflammatory biomarkers are also described.

引用

页数：14

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