A matter of life or death (or both): Understanding autophagy in cancer

被引：61

作者：

Hait, WN

Jin, SK

Yang, JM

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, Dept Med, New Brunswick, NJ 08903 USA

[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, Dept Pharmacol, New Brunswick, NJ 08903 USA

来源：

CLINICAL CANCER RESEARCH | 2006年 / 12卷 / 07期

关键词：

D O I：

10.1158/1078-0432.CCR-06-0011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Autophagy is a highly conserved pathway that can be used for survival during nutrient and growth factor deprivation. Under certain circumstances, it seems that autophagy may serve as a pathway to cell death. Already, it is becoming increasingly clear that autophagy is involved in cancer formation, survival, and response to several forms of cancer treatments. A detailed understanding of how this pathway is regulated is now emerging and will allow translation of this information into new approaches to cancer treatment. © 2006 American Association for Cancer Research.

引用

页码：1961 / 1965

页数：5

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