Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins

被引:498
作者
Bickel, PE
Scherer, PE
Schnitzer, JE
Oh, P
Lisanti, MP
Lodish, HF
机构
[1] WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA 02142 USA
[2] MASSACHUSETTS GEN HOSP, DEPT MED, DIABET UNIT, BOSTON, MA 02114 USA
[3] HARVARD UNIV, SCH MED, BOSTON, MA 02114 USA
[4] HARVARD UNIV, SCH MED, BOSTON, MA 02114 USA
[5] HARVARD UNIV, SCH MED, DEPT PATHOL, BOSTON, MA 02215 USA
[6] BETH ISRAEL HOSP, BOSTON, MA 02215 USA
[7] MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA
关键词
D O I
10.1074/jbc.272.21.13793
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Caveolae are plasmalemmal microdomains that are involved in vesicular trafficking and signal transduction. We have sought to identify novel integral membrane proteins of caveolae. Here we describe the identification and molecular cloning of flotillin. By several independent methods, flotillin behaves as a resident integral membrane protein component of caveolae. Furthermore, we have identified epidermal surface antigen both as a flotillin homologue and as a resident caveolar protein. Significantly, flotillin is a marker for the Triton-insoluble, buoyant membrane fraction in brain, where to date mRNA species for known caveolin gene family members have not been detected.
引用
收藏
页码:13793 / 13802
页数:10
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