Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases

被引：412

作者：

Musti, AM ^{[1
]}

Treier, M ^{[1
]}

Bohmann, D ^{[1
]}

机构：

[1] EUROPEAN MOL BIOL LAB,D-69117 HEIDELBERG,GERMANY

来源：

SCIENCE | 1997年 / 275卷 / 5298期

关键词：

D O I：

10.1126/science.275.5298.400

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The proto-oncogene-encoded transcription factor c-Jun activates genes in response to a number of inducers that act through mitogen-activated protein kinase (MAPK) signal transduction pathways. The activation of c-Jun after phosphorylation by MAPK is accompanied by a reduction in c-Jun ubiquitination and consequent stabilization of the protein. These results illustrate the relevance of regulated protein degradation in the signal-dependent central oi gene expression.

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页码：400 / 402

页数：3

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