New insights into the mechanism of IL-1β maturation

被引：125

作者：

Burns, K ^{[1
]}

Martinon, F ^{[1
]}

Tschopp, J ^{[1
]}

机构：

[1] Univ Lausanne, Inst Biochem, CH-1066 Epalinges, Switzerland

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(02)00017-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pro-inflammatory cytokine IL-1beta is initially synthesised in an inactive precursor form and therefore requires processing by caspase-1 for activation. Recently, several investigators have identified a number of proteins that are implicated in caspase-1 activation, and other proteins that negatively regulate both caspase-1 activation and IL-1beta processing have also been identified. Drugs that target these components may have therapeutic benefits for inflammatory diseases.

引用

页码：26 / 30

页数：5

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