Ambiguous results in functional neuroimaging data analysis due to covariate correlation

被引：98

作者：

Andrade, A ^{[1
]}

Paradis, AL

Rouquette, S

Poline, JB

机构：

[1] Commissariat Energie Atom, Serv Hosp Frederic Joliot, F-91401 Orsay, France

[2] Univ Lisbon, Fac Ciencias, Inst Biofis & Engn Biomed, P-1699 Lisbon, Portugal

[3] Coll France, CNRS, Lab Physiol Percept & Act, F-75231 Paris, France

来源：

NEUROIMAGE | 1999年 / 10卷 / 04期

关键词：

D O I：

10.1006/nimg.1999.0479

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this note we draw attention to a source of potential ambiguity in functional neuroimaging results when data analysis is based on the resolution of a linear model. This ambiguity arises whenever there exists correlation between the model covariates. A single-subject PET activation experiment helps to illustrate to what extent correlation can affect statistical results interpretation, possibly leading to misinterpretation of part of the activation pattern. This note is intended to clarify this point and to suggest the use of a simple and well-known procedure to deal with these situations. In the Appendix, we suggest a convenient mathematical formulation for statistical tests particularly useful in such cases. (C) 1999 Academic Press.

引用

页码：483 / 486

页数：4