Mechanisms of caspase activation and inhibition during apoptosis

被引：1616

作者：

Shi, YG ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Lewis Thomas Lab, Princeton, NJ 08544 USA

来源：

MOLECULAR CELL | 2002年 / 9卷 / 03期

关键词：

D O I：

10.1016/S1097-2765(02)00482-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caspases are central components of the machinery responsible for apoptosis. Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome have revealed a conserved mechanism of caspase activation and inhibition. This article reviews these latest advances and presents our current understanding of caspase regulation during apoptosis.

引用

页码：459 / 470

页数：12

共 85 条

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