Recent advances in identifying and validating drug targets in trypanosomes and leishmanias

被引：103

作者：

Barrett, MP ^{[1
]}

Mottram, JC

Coombs, GH

机构：

[1] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow G11 6NT, Lanark, Scotland

[2] Univ Glasgow, Wellcome Unit Mol Parasitol, Glasgow G11 6NT, Lanark, Scotland

来源：

TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0966-842X(98)01433-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The unique aspects of the biochemistry of trypanosomatids make rational drug design an attractive approach, but targets must be selected carefully. Genetic manipulation provides a valuable means of mimicking loss of function attributable to therapeutic intervention, but caution must be exercised when interpreting such data with respect to target validation.

引用

页码：82 / 88

页数：7

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