TLR signaling

被引：1627

作者：

Kawai, T

Akira, S

机构：

[1] Osaka Univ, Res Inst Microbial Dis, Dept Host Def, Suita, Osaka 5650871, Japan

[2] Japan Sci & Technol Agcy, ERATO, Suita, Osaka 5650871, Japan

来源：

CELL DEATH AND DIFFERENTIATION | 2006年 / 13卷 / 05期

关键词：

innate immunity; signal transduction; inflammatory cytokines; type I interferon; toll-like receptors;

D O I：

10.1038/sj.cdd.4401850

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Toll-like receptor (TLR) family plays an instructive role in innate immune responses against microbial pathogens, as well as the subsequent induction of adaptive immune responses. TLRs recognize specific molecular patterns found in a broad range of microbial pathogens such as bacteria and viruses, triggering inflammatory and antiviral responses and dendritic cell maturation, which result in the eradication of invading pathogens. Individual TLRs interact with different combinations of adapter proteins and activate various transcription factors such as nuclear factor (NF)-kappa B, activating protein-1 and interferon regulatory factors, driving a specific immune response. This review outlines the recent advances in our understanding of TLR-signaling pathways and their roles in immune responses. Further, we also discuss a new concept of TLR-independent mechanisms for recognition of microbial pathogens.

引用

收藏

页码：816 / 825

页数：10

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